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Showing posts from May, 2016

Which came first: Beer or wine? (or something else?)

Actually neither beer nor wine was the first fermented beverage, and wine arguably has a closer connection to health, but recent evidence indicates that humans developed the ability to metabolize alcohol long before we were even human. The uniquely human ability to handle alcohol comes from the digestive enzyme alcohol dehydrogenase, or ADH4. A new science called paleogenetics identifies the emergence of the modern version of the ADH4 gene in our ape ancestors some 10 million years ago. Interestingly, this corresponds to the time when our arboreal forebears transitioned to a nomadic lifestyle on the ground. We went from swinging from tree limbs to walking upright, and the rest is history. Understanding the circumstances that led to perpetuation of the ADH4 mutation may contain clues to what made us human in the first place. How the ability to metabolize alcohol made us human Paleogenetecist Matthew Carrigan has an idea about how this happened. Arboreal species rely on fruit that is …

More evidence that resveratrol is not the same as wine (and may be worse)

It has become common to think of the antioxidant molecule resveratrol as the main beneficial ingredient in wine, but a new study sheds light on how resveratrol without the other components of wine might actually be a bad thing. Sure, resveratrol is a miracle molecule, providing a plausible explanation for many of the health benefits of moderate drinking: lower odds of diabetes, cancer, osteoporosis, even longer life by activation of longevity genes. I leaned heavily on these findings in the book. But what I didn’t anticipate was that resveratrol would become such a hugely popular supplement, and in many people’s minds it became a proxy for wine. If a study showed some failing of resveratrol in a laboratory study, it was put out as a denunciation of healthy drinking. Or when it showed some positive effect in mice, it was hailed as proof that resveratrol had all the benefits of wine – without the alcohol. Both are oversimplifications.

Resveratrol works best when combined with other wine …